Btc coupling reagent

btc coupling reagent

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BITCOIN AL CORTO!! ANALISIS Y PROYECCION DE BTC ?? ?DIVERGENCIA BAJISTA?
The BTC-mediated coupling of all Fmoc-protected | Solid-Phase Synthesis (BTC) was found to be the most efficient activating reagent. 53,55,60,61,62, Triphosgene (bis(trichloromethyl) carbonate (BTC) is a chemical compound with the formula OC(OCCl3)2. It is used as a solid substitute for phosgene. The reagent bis-(trichloromethyl)carbonate (BTC) (Councler, C. Ber. Dtsch. Chem. Ges. , ) also named hexachlorodimethyl carbonate or "triphosgene" is.
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In order to find the limitations of BTC to promote difficult couplings we synthesized peptides in which various Phe building units were coupled to N-Me-Ala-peptidyl-resin. Triphosgene has been used as an efficient carbonylating agent for liquid and solid phase synthesis of various aza-analogues of peptides containing aza-alanine, aza-aspartic acid and aza-asparagine residues Andre et al. Table 3.